In the all-female support series, the 20-year-old Frenchwoman will drive a Mercedes-liveried car run by Prema, the team she runs with in sportscars and Formula 4.
"I am incredibly happy to join the Mercedes-AMG F1 Team Junior Programme and to represent the team in F1 Academy this year with Prema Racing," Pin said.
"A new chapter begins, and I am proud to make this next step in such a prestigious team and with the Iron Dames project. I am grateful for their trust and honoured to race for their colours.
"Moving into single-seaters was a clear objective for my career, and to be in this environment is a great approach. I am working very hard to reach the top level of this sport and I cannot wait to go racing."
Mercedes F1 boss Toto Wolff said his team had kept a "close eye" on Pin's development for years, meaning she was an obvious choice once all F1 teams committed to running one car in the F1 Academy from 2024 onwards.
"Doriane is an exciting talent and we're pleased to begin our participation in F1 Academy with her as our chosen driver," Wolff said.
"We have kept a close eye on her development in recent years as she has consistently impressed. The fantastic support of Deborah Mayer and the Iron Dames organisation has enabled her to display her abilities to this point; she has taken full advantage of that opportunity with determination and skill."
Source: Autosport