The 41-year-old German driver published a statement on social media confirming that he will focus solely on his Porsche commitments in the World Endurance Championship in 2024.
It brings down the curtain on a six-season spell in Formula E that began when he joined Techeetah for the 2017/18 season, as well as more than two decades racing in single-seaters.
In that time, Lotterer won the Formula Nippon title in 2011 and made a single Formula 1 start for Caterham at Spa in 2014.
"It’s time for me to close a 26-year chapter of single-seater racing," read the statement.
"I have decided not to race anymore in the FIA Formula E World Championship to fully focus on my challenge with Porsche to win the Le Mans 24 Hours for the fourth time and the FIA World Endurance Championship.
"It has been a great ride racing in Formula BMW, Formula Renault, Formula 3, Champ Car, Formula Nippon/Super Formula, Formula 1 and finally the Formula E family which I joined at the start of season four back in 2017.
"I would like to personally thank [series co-founder] Alejandro Agag, his team and the FIA for creating Formula E, it has been a fantastic journey and you have changed many of our lives. Formula E has been the most challenging and fun championship I have competed in!
"I am extremely grateful and proud to have raced in Formula E, promoting all the sustainable technologies and for meeting the amazing people in this paddock, a few of whom have become my best friends today."
Source: Autosport