Verstappen crossed the line with a whopping 33.7s lead over Lando Norris, who had to deal with a late fright from Sergio Perez for second before the Mexican was challenged by Hamilton for third at the end.
Hamilton was slower away off the line compared to Verstappen and attempted to bear right along the straight to defend, but could not prevent the championship leader from claiming the lead into the first corner.
As the two had taken wider lines into Turn 1, Oscar Piastri grabbed the initiative and slotted his McLaren down the inside to come up for air with second.
Verstappen then began to stretch his newly acquired gap despite the array of tyre management being carried out amid the 29C heat, and spent the opening laps building up his advantage.
Lando Norris, who had passed Hamilton for third on a difficult opening lap for the seven-time champion, called into the pits at the end of lap 17 for a set of hard tyres, with Piastri to follow on the next lap.
But a rapid outlap allowed Norris to blast past his McLaren team-mate and claim a net second place, and the Briton's next few tours of the circuit ensured that he could build a buffer over his team-mate.
Verstappen then pitted at the end of lap 23 for the hard tyre, and Norris's collection of opening laps on that compound closed the gap between the front two to just 5.4 seconds.
Source: Autosport