Its expansion into North America's premier open-wheel championship is a notable move for one of the most successful junior formula programmes in history, which has 80 titles and counting over its 40 years in operation.
Prema's venture follows Carlin's short-lived effort in the series and will see the Italian team enter the Indianapolis 500 for the first time.
"Today's announcement marks a pivotal moment in the history of Prema Racing,” said Team Principal Rene Rosin.
“Making the step to the IndyCar Series, and competing in the world-famous Indianapolis 500, is a dream coming true for our family and everyone involved in our business.
“We have tremendous respect for IndyCar, its unique challenges and sensational history, and we look forward to being part of it.
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“While competing in IndyCar will not be easy, we are determined to put in our best effort, learn as quickly as possible and become leading contenders right from the start.
“The desire to fight for victory is our driving force, and the thoroughness of the challenge will give us even more motivation to succeed.
“This new chapter will also be beneficial for Prema Racing and its people, producing amazing learning opportunities and know-how transfer.
Source: Autosport