The reigning world champion crossed the line with a 22.4-second gap over Perez to clinch his eighth successive F1 win, stretching back to his Suzuka win last year.
Verstappen faced little in the way of competition, only having to contend with a brief play for the lead from Charles Leclerc into the first corner as the Ferrari driver attempted to make a pass around the outside.
But the Red Bull driver held the racing line and kept Leclerc at arm's length.
Although Leclerc may have hoped for some early assistance from the revised DRS regulations, which allows the overtaking aid to be activated from the second lap, Verstappen had already galloped to a one-second advantage to ensure there were no challenges on the next lap.
Early battles for second gave Verstappen more breathing space and, after George Russell had mounted a pass on Leclerc, the Mercedes was not able to make further inroads and the Dutchman extended his lead to three seconds by the end of lap four.
It was a typical Verstappen drive, with relentless consistency and excellent tyre management as Red Bull arguably took a less conservative strategy relative to the other runners; having saved a set of softs from earlier in the weekend, Verstappen and Perez both ran to a soft-hard-soft two-stopper while the others elected to stick to a soft-hard-hard strategy.
Verstappen managed to take his opening stint as far as the end of lap 17 as he became the last driver to pit, but was far enough ahead of Perez - who had since passed Russell for second on lap 14 with an up-and-under overtake into Turn 4 - to maintain a five-second lead.
This grew as Perez faced challenges from Russell and Carlos Sainz behind him, ensuring that Verstappen could focus on maintaining a consistent pace at the head of the field.
He made his final stop on lap 37, switching from his sole set of hard tyres back to the softs, which he was able to press into service for a statement 1m32.608s lap before easing back into a strong race pace.
Perez had to spend the race's second half keeping Sainz at bay, as the Spaniard proved the quicker of the Ferrari drivers throughout the course of the race.
Source: Autosport