Both Friday's qualifying and Saturday's race will start at 10pm Nevada time, with the latter potentially running until after midnight if there is a red flag delay and restart.
Records suggest that in mid-November, ambient temperature is likely to dip below 10 degrees Celsius, and it could go as low as five degrees.
Those sorts of numbers will clearly put a premium on getting the tyres into the right window, especially for qualifying laps, at the start, and after safety car restarts.
"It'll just depend on exactly how cold it is," said Mercedes trackside engineering director Andrew Shovlin when asked by Autosport about the challenge.
"Because if the track is down in single figures, that's often a region where you go winter testing.
"You do a run, it's very difficult for the tyres to either get them switched on, or there may be graining and things. And then sometimes you just wait until it warms up a bit.
"So actually having to sort of race and qualify in those conditions, it will be interesting.
"You just try and identify the risks with the new circuit, work out what your contingencies will be, whether you need any sort of specific car spec to deal with that. And we're going through that at the moment.
"But as I said, if it's at the very cold end of predictions, it's difficult to know how the tyres are going to work."
Source: Autosport