Perez went off at the exit of the iconic Parabolica corner, bringing out a second red flag in the session topped by Ferrari's Carlos Sainz.
Perez was fortunate to escape with only minor contact with the outside barriers, tapping the wall with his rear wing.
Explaining the crash Perez said: "I understeered off on the exit and I tried to keep it nailed. I thought I had it under control but then I touched a bit of the gravel and that was game over.
"It doesn't look too bad, the damage. It was fairly small, so I don't think we lost anything in the end. A few laps, so nothing representative in that regard."
The incident didn't dent an otherwise "very strong" session for Perez, calling it his "best Friday in a while" after finding a solid set-up baseline with the RB19.
"The positive is that the car is performing well. I'm feeling comfortable with it," he explained after finishing third-fastest just 0.185s behind pacesetter Sainz.
"And I think we are in a good position for the rest of the weekend. I really felt that we had a very strong Friday.
Source: Autosport