Bautista will contest the Sepang event on a factory-supported Desmosedici GP22 in the colours of Aruba.it, the title sponsor of the works Ducati WSBK outfit, on 10-12 November.
It will mark the 38-year-old Spaniard's first grand prix appearance since the end of the 2018 season, the year before he made the switch to Superbikes with the Borgo Panigale marque.
Bautista has already undertaken two tests with the GP22 he will ride in Malaysia at Misano, one in June and then again last week.
Ducati agreed to hand Bautista a MotoGP outing as a reward for his championship success in WSBK last year, which marked the brand's first riders' title in more than a decade.
Bautista is thought to have pushed for the wildcard to take place at Sepang, one of his favourite tracks, rather than at the season finale at Valencia, which was Ducati's original preference for cost reasons.
"I'm really happy to be able to race in MotoGP as a wildcard at Sepang, a track that I really like and that I'm happy to be back at since it's not on the WSBK calendar," he said. "The tests with the Ducati Desmosedici GP gave positive feedback: the feeling was good, and I had fun.
Source: Autosport