Aston reserve driver Vandoorne will share driving duties with team regular Lance Stroll, while Lando Norris and Oscar Piastri will have a day apiece for McLaren.
It will be the Belgian's first on-track outing in a current F1 car since he drove for Mercedes in the Abu Dhabi test in December 2020.
While the focus of the Spa test is on Pirelli's blanket-free tyres, it will give Vandoorne a valuable opportunity to sample the 2023 car, thus helping him with correlation of his simulator work for Aston Martin.
It will also make his life a lot easier should he be called upon if either Stroll or Fernando Alonso is indisposed at any point over the remainder of the season.
The 31-year-old shares the Aston reserve role with reigning Formula 2 champion Felipe Drugovich, with the pair taking turns to attend races on standby.
Drugovich had his own chance to sample the AMR23 when he drove it for two days at the Bahrain test in February while Stroll was not available. Since then, the Brazilian has been amassing further mileage in private testing in a 2021 car.
Source: Autosport