The 2020 world champion crashed during the second practice session of the Italian GP weekend and fractured the little finger on his right hand.
He withdrew from the remainder of the Italian GP with the hopes of being fit enough to race at the Sachsenring this weekend.
However, Honda has now confirmed the Spaniard will take no part in the German GP, compounding what has already been a miserable season for him. He will not be replaced.
Mir's move to the factory Honda squad after Suzuki quit MotoGP at the end of 2022 has been plagued by misfortune.
So far, he has scored just five points, having crashed out of the Portugal and Argentina sprints, the Americas GP, both contests in Spain and the grand prix in France.
His crash tally for the season has been 12, matching his own record from his rookie year in 2019.
Mir admitted after the French GP that he was "scared" about repeating the failures at Honda experienced by the likes of Jorge Lorenzo and Pol Espargaro, who both endured torrid years on the RC213V at the factory squad.
Source: Autosport