The Prema Racing driver, in his second F2 season, took a lights-to-flag win to repeat his success in Saudi Arabia.
The race was red-flagged after a crash for Virtuosi driver Doohan at Turn 3 saw his car burst into flames, prompting a clean-up operation which stalled action for 20 minutes.
Vesti crossed the line 2.5s clear of second-placed Theo Pourchaire, who faces a post-race investigation for a pitlane infringement.
Rodin Carlin rookie Zane Maloney finished third for his second podium of the season.
The top three stayed the same into Turn 1 at the start, despite Pourchaire initially losing ground to Jack Doohan before getting back ahead.
MP Motorsport’s Jehan Daruvala lost out at the start to Red Bull juniors Ayumu Iwasa (DAMS) and Isack Hadjar of Hitech, dropping to 10th.
Further back, Oliver Bearman made up two places on the first lap in his Prema-run car, passing Amaury Cordeel (Virtuosi) and MP Motorsport’s Dennis Hauger for 12th.
Cordeel continued to fall down the order before retiring on lap three.
By lap five, Vesti had built a one-second gap to Martins, with another 2.6s between the two ART cars.
Iwasa and Hadjar were embroiled in a fierce fight for eighth, with the Japanese driver holding firm despite the challenge.
Clement Novalak (Trident) and Campos’ Ralph Boschung were first to pit on lap seven, switching from the super softs to the soft Pirelli compound.
Heartbreak came for home favourite Arthur Leclerc the following tour as he lost brakes on his DAMS-run entry, cutting the Nouvelle Chicane before crawling back to the pits.
The stops continued over the next few laps, with Jak Crawford leading the stoppers for Hitech as Iwasa and Hadjar followed suit.
Source: Autosport