Wallace's 23XI Toyota led the way on the start of the final lap in second overtime, but Blaney was closing fast to challenge for the lead.
Wallace moved high, then low to block and finally on the third attempt got hit by Blaney to trigger a multi-car wreck that ended the race under caution.
Busch, who had lined up third to start the second overtime, was ahead of Blaney when the caution was displayed and declared the winner. He led three times in the race for a total of three laps, including the last one.
The win is the second of the 2023 season for Busch, who claimed his first win for Richard Childress Racing at Fonatana earlier this year. His 62nd career victory was the first for Busch at Talladega since 2008.
“Sometimes you got to be lucky,” Busch said. “Some of these races come down to that.
"You got to take them when they come your way. The seas kind of parted there when they went up the race track.
"They were trying to push-draft. These cars are just not stable enough to do that.
“I saw (Wallace) just turn a little bit sideways. I was like, ‘Get out of the way, just miss it.’ Tried to see if I was ahead of (Blaney) by the time it was called.”
Before the start of the second overtime, Busch’s team quizzed him on pitting for fuel but he opted not to. Asked how close he was to running out, Busch said: “It shut off right here when I was trying to do a burnout.
Source: Autosport